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Table 3 Combined toxicity (Grade 3-4) results.

From: Magnitude of benefit of the addition of bevacizumab to first-line chemotherapy for metastatic colorectal cancer: meta-analysis of randomized clinical trials

Outcomes

Pts (RCTs)

RR (95% CI)

p-value

Het. (p)

AD (%)

NNH

HTN

2,728 (5)

4.87 (3.12, 7.61)

< 0.0001

0.93

6.2

16

Bleeding

2,570 (4)

1.72 (0.96, 3.07)

0.07

0.52

-

-

Proteinuria

2,570 (4)

2.10 (0.64, 6.84)

0.21

0.56

-

-

  1. Pts: patients; RCTs: randomized clinical trials; RR: relative risk; CI: confidence intervals; Het.: heterogeneity; AD: absolute difference; NNH: number needed to harm; HTN: hypertension.
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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