Relationship and prognostic significance of SPARC and VEGF protein expression in colon cancer

Table 3 Relationship of VEGF expression and MVD with clinicopathologic parameters and SPARC expression

Parameters		VEGF				P value	MVD (CD34)	P value
		(-)	(1+)	(2+)	(3+)		(mean ± S.D.)	(ANOVA)
Total	114	31	27	22	34		11.60 ± 5.68
Age						0.612		0.319
< 59	48	11	10	10	17		12.23 ± 6.19
≥ 59	66	20	17	12	17		11.15 ± 5.28
Tumor differentiation						0.112		0.952
low	16	6	2	3	5		11.24 ± 7.30
moderate	68	16	18	9	25		11.72 ± 5.30
high	30	9	7	10	4		11.53 ± 5.75
Lymph node metastasis						0.001		0.879
N0	65	23	20	13	9		11.80 ± 5.54
N1	36	7	6	7	16		11.20 ± 6.74
N2	13	1	1	2	9		11.74 ± 2.59
depth of invasion						0.601		0.281
T2	15	5	3	4	3		11.28 ± 5.63
T3	88	24	21	14	29		11.33 ± 5.66
T4	11	2	3	4	2		14.20 ± 5.72
TNM staging						0.002		0.295
I	11	4	3	3	1		12.00 ± 6.00
II	47	17	15	8	7		10.99 ± 4.70
III	44	8	6	6	24		11.04 ± 6.26
IV	12	2	3	5	2		14.26 ± 5.46
SPARC in MSC						0.0001		0.027
low reactivity	61	17	6	13	25		12.69 ± 5.71
high reactivity	53	14	21	9	9		10.34 ± 5.43

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