Figure 5From: Comparison of the inhibitory effects of three transcriptional variants of CDKN2A in human lung cancer cell line A549Cell growth inhibition and cell cycle redistribution effects of p16INK4a in A549 cells. Cell growth curve in a representative experiment (a) and analysis of the differential inhibition effects of the three variants in three independent experiments carried out after 72 h of subculture (b). Significant growth retardance was exerted by p16INK4a compared with the control. The protein was transduced the day before cell counting. Data shown are the mean ± standard deviation of triplicate wells or experiments. **p < 0.01. c. p16INK4a protein caused evident accumulation of A549 cells in G1 phase and a decrease of those in S phase at 48 h after subculture. Data shown are the mean ± standard deviation of three independent experiments. *p < 0.05.Back to article page