Figure 6

Adaphostin (ADA) toxicity is enhanced when HMOX1 induction is diminished via inhibition of Nrf2 nuclear translocation by wortmannin. NCI-H522 cells were pretreated with 250 nM wortmannin, followed by treatment with ADA for an additional 96 h and growth inhibition was assessed with alamarBlue vital dye (n = 4; +/- SD; * indicates p = or <0.01).