Table 3 Comparison of toxicities between wild type and variant allele groups for VEGFR2 SNPs
Toxicity grade ≥2 N (%*) | VEGFR2 H472Q | VEGFR2 V297I | ||||
|---|---|---|---|---|---|---|
wt allele | var allele | p-value† | Wt allele | var allele | p-value† | |
HT | 22 (21.4) | 26 (38.8) | 0.0154 | 38 (29.0) | 12 (30.8) | 0.84 |
HFSR | 16 (15.5) | 22 (32.8) | 0.0136 | 28 (21.4) | 10 (25.6) | 0.66 |
Rash:desquamation | 17 (25.0) | 13 (28.9) | 0.67 | 23 (27.7) | 9 (30.0) | 0.82 |
Diarrhea | 14 (20.6) | 7 (15.6) | 0.62 | 19 (22.9) | 3 (10.0) | 0.18 |
Fatigue | 12 (17.7) | 6 (13.3) | 0.61 | 14 (16.9) | 4 (13.3) | 0.78 |