Figure 5

Ultrasound microbubble-mediated siMDR1 delivery enhances the sensitivity of L2-RYC cells to chemotherapeutic drugs. Experimental groups I to V were same as that described in figure 2. Treated cells were replanted into 96-well plates. Chemotherapeutic drugs were added into the culture at different concentrations. MTT assay was performed, and then plates were read at 520 nm by spectrophotometer. Sensitivity to chemotherapeutic drugs was determined by using cell viability and IC₅₀ value. (A) Cell viability of each experimental group at different concentrations of Vincristine, (B) IC₅₀ value for Vincristine in each group. (*P < 0.05, vs other groups), (C) Cell viability of each experimental group at different concentrations of Dactinomycin, (D) IC₅₀ value for Dactinomycin in each group. (*P < 0.05, vs other groups)