Figure 4

Iv vivo images of tumor-bearing mice show the tumor targeting effect of anti-Sp17-ICG-Der-02 (dose for each group was 0.2 μg, calculated as the amount of ICG-Der-02). A. Systemic injection of anti-Sp17-ICG-Der-02 (n = 5). Images were obtained in one mouse; bright fluorescent in the tumor region is due to probe accumulation. B. Systemic injection of free ICG-Der-02 (n = 3), images were obtained in one mouse, fluorescent signal in tumor is virtually absent.