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Table 2 Univariate and multivariate analyses of individual variables for correlations with overall survival: cox proportional hazards model

From: Clinicopathological significance of non-small cell lung cancer with high prevalence of Oct-4 tumor cells

Variables

Univariate

Multivariate

 

HR

95%CI

P

HR

95%CI

P

Age

0.988

0.969-1.008

0.231

1.001

0.978-1.025

0.922

Gender

0.852

0.517-1.405

0.530

0.525

0.305-0.906

0.121

Smoking

1.179

0.740-1.880

0.489

1.277

0.743-2.195

0.376

Histological type

1.087

0.697-1.695

0.713

1.168

0.706-1.932

0.546

Histological differentiation

3.727

2.139-6.495

< 0.001

3.666

1.937-6.939

0.001

Local advance

1.282

0.920-1.731

0.149

1.222

0.928-1.609

0.153

Lymph node metastasis

1.487

1.148-1.927

0.003

1.042

0.743-1.461

0.813

Oct-4 expression

1.105

1.007-1.024

< 0.001

1.011

1.003-1.020

0.009

Age

0.990

0.963-1.018

0.482

1.014

0.978-1.051

0.450

Gender

0.786

0.408-1.512

0.470

0.296

0.087-1.008

0.052

Smoking

1.231

0.646-2.346

0.527

0.733

0.237-2.265

0.590

Histological type

0.785

0.408-1.512

0.470

0.869

0.386-1.956

0.735

Histological differentiation

1.428

0.701-2.910

0.327

1.418

0.591-3.405

0.434

Local advance

1.191

0.780-1.817

0.418

0.934

0.560-1.558

0.793

Lymph node metastasis

1.217

0.833-1.778

0.310

1.560

0.976-2.495

0.063

Oct-4 expression

1.014

1.002-1.025

0.021

1.024

1.007-1.042

0.005

Age

0.994

0.965-1.024

0.688

1.005

0.967-1.044

0.801

Gender

0.790

0.395-1.580

0.505

0.401

0.166-0.966

0.096

Smoking

1.232

0.635-2.389

0.537

0.921

0.382-2.219

0.855

Histological type

1.439

0.767-2.700

0.257

1.247

0.598-2.600

0.556

Histological differentiation

1.925

0.934-3.969

0.076

1.962

0.791-4.868

0.146

Local advance

1.313

0.822-2.099

0.254

1.231

0.743-2.042

0.420

Lymph node metastasis

1.415

0.953-2.103

0.086

1.472

0.933-2.323

0.097

Oct-4 expression

1.010

0.999-1.022

0.018

1.011

0.998-1.024

0.042

  1. Variable 1, Oct-4 expression was an independent prognostic factor, adjusted by histological differentiation, in all cases
  2. Variable 2, Oct-4 expression was an independent factor in MVD-negative cases
  3. Variable 3, Oct-4 expression was an independent factor in VEGF-negative cases
  4. Abbreviations: HR, hazard ratio; CI, confidence interval