Figure 3From: GCS overexpression is associated with multidrug resistance of human HCT-8 colon cancer cellsKnocking down GCS causes HCT-8/VCR more sensitive to cisplatin induced cell death. HCT-8, HCT-8/VCR, HCT-8/VCR sh-mock or sh-GCS stably transfected cells (5 × 103) were seeded in 96-well in 100 ul PRMI-1640 medium. Cells were treated with different concentaration of cisplatin for 48 h. The relative drug resistance folds were analyzed by compared with IC50. The cell survival rate of cells without cisplatin complexes was set as 100%. *Ρ < 0.01 compared with the HCT-8/VCR and HCT-8/VCR-sh-mock cells.Back to article page