From: Detection of EGFR mutations in circulating free DNA by PNA-mediated PCR clamping
Year | Authors | Subjects | DNA concentration | Mutation test | Detection rate |
---|---|---|---|---|---|
2006 | Kimura H, et al. [16] | Asian | 70 ng/mL (range, 0–1720 ng/mL) | SARMS | 48.1% (13/27) |
Female : 37% | |||||
Nonsmoker : N/A | |||||
ADC : 85% | |||||
ORR : 33% | |||||
2008 | Maheswaran S, et al. [24] | Western | N/A | SARMS | 39% (7/18) |
EGFR mutant patients | |||||
2009 | He C, et al. [29] | Asian | N/A | Mutant-enriched PCR | 49.3% (66/134) |
Female : 37% | |||||
Nonsmoker : 53% | |||||
ADC : 75% | |||||
2009 | Bai H, et al. [28] | Asian | N/A | dHPLC | 34.3% (79/230) |
Female : 46% | |||||
Nonsmoker : 55% | |||||
ADC : 74% | |||||
ORR : 36% (37/102) | |||||
2009 | Mack PC, et al. [26] | Western/Asian : 96/4% | 2.3 ng/μL (range, 1–9 ng/μL ) | SARMS | 20% (10/49) |
Female : 56% | |||||
Nonsmoker : 53% | |||||
ADC : 67% | |||||
2009 | Kuang Y, et al. [25] | Western | 52.3 ng/μL (range, 10–163 ng/μL ) | SARMS and WAVE/Surveyor | 54% (29/54) |
Female : 81.5% | |||||
Whole genome amplification | |||||
Nonsmoker : N/A | |||||
ADC : N/A | |||||
ORR : 56% | |||||
2010 | Brevet M, et al. [31] | Western | N/A | Mass spectrometry genotyping assay (Sequenom) and mutant-enriched PCR Whole genome amplification | 23.2% (10/31) |
Female : 52% | |||||
Nonsmoker : 45% | |||||
ADC : 97% | |||||
2010 | Jian G, et al. [27] | Asian | N/A | Taqman PCR | 23.2% (13/56) |
Female : 46% | |||||
Nonsmoker : 58% | |||||
ADC : 78% | |||||
ORR : 30% | |||||
2011 | Jiang B, et al. [30] | Asian | Minimum 4 ng/μL (range, 11–66 ng/μL ) | Mutant-enriched PCR | 31% (18/58) |
Female : 31% | |||||
Nonsmoker : 38% | |||||
ADC : 72% | |||||
2011 | Taniguchi K, et al. [32] | Asian | N/A | BEAMing | 72.7% (32/44) |
EGFR mutant patients | |||||
This study | Kim HR, et al. | Asian | 8.6 ng/μL | PNA-based PCR clamping | 16.7% (10/60) |
Female : 65% | |||||
Nonsmoker : 2% | |||||
ADC : 88% | |||||
 |  | ORR : 100% |  |  |  |