From: Pharmacokinetic study and evaluation of the safety of taurolidine for dogs with osteosarcoma
Dog ID # | 7 | 8 | 9 | 10 | 11 | 12 | 13 |
Weight (kg) | 56 | 74 | 64 | 37 | 28 | 47 | 30 |
Breed | Great Pyrenees | Irish wolfhound | Great Pyrenees | Golden retriever | Shepherd mix | Labrador cross | Old English sheepdog |
Age (yr) | 6 | 4 | 6 | 7 | 11 | 7 | 5 |
Sex | Neutered male | Spayed female | Spayed female | Neutered male | Spayed female | Neutered male | Spayed female |
Tumor location | Distal radius | Distal radius | Distal radius | Proximal tibia | Proximal humerus | Distal radius | Distal radius |
Chemo drug | Doxorubicin | Doxorubicin | 1 dose doxorubicin then carboplatin | Carboplatin | Carboplatin | Carboplatin | Carboplatin |
Number of taurolidine treatments | 4 | 10 | 4 | 5 | 3 | 5 | 2 |
Neutropenia | None | None | Grade 1 onceb | Grade 1 four times | None | Grade 1 once | Grade 1 once |
Grade 2 once | Grade 2 once | ||||||
Thrombocytopenia | None | Grade 1 twice | None | None | None | Grade 2 once | None |
Grade 2 twice | |||||||
Chemistry panel | Normal | Low albumin, high ALP which returned to normal in 2 weeks | Azotemiab | Normal | Normal | ALT elevationc | Normal |
Constitutional adverse event | Lethargy grade 1 to 2a | Grade 1 fever once | Lethargy grade 1 once | Lethargy grade 1 once | Grade 2 fever and lethargy grade 3 once, both associated with extravasation of carboplatin or taurolidine | Lethargy grade 1 twice and grade 2 twice | None |
GI toxicity | Anorexia grade 2a | Anorexia grade 1 twice | Diarrhea grade1b | None | None | Anorexia grade 1 once and grade 2 twice | Anorexia grade 1 once |
Diarrhea grade 1 once | Diarrhea grade 1 once | ||||||
Other adverse event or complication | Edema in limb which was used for IV infusion, vasculopathy at injection sites | Phlebitis and limb edema | Renal insufficiencyb | None | Hearing loss | None | None |
Congestive heart failure | |||||||
Proteinuria (urine protein/creatinine = 7.9) nephropathy | |||||||
Outcome | Euthanized due to progressive disease a,e | Died of heart failuree | Bone metastasis documented 1071 days postoperativelye | Died 897 days postoperatively with pulmonary metastasisd,e | Euthanized 174 days postoperatively due to pulmonary metastasise | Euthanized 165 days postoperatively due to metastasis to scapulae | Euthanized 116 days postoperatively due to metastasis to lungs, liver, and spine d, e |
Necropsy performed | Necropsy performed | Still alive 1186 days postoperatively | Necropsy performed | Necropsy performed |