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Table 4 Number of events for toxicities associated with the administration of taurolidine to dogs with osteosarcoma

From: Pharmacokinetic study and evaluation of the safety of taurolidine for dogs with osteosarcoma

Toxicity

Grade I

Circumstances

Grade II

Circumstances

Bone marrow

    

  Neutropenia

7

1 when T combined with D

2

Both when T combined with C

6 when T combined with C

  Thrombocytopenia

2

1 when T alone

3

2 when T combined with D

1 when T combined with D

1 when T combined with C

Gastrointestinal

    

  Anorexia

4

2 when T combined with D

5

3 when T combined with D

1 when T combined with C

2 when T combined with C

1 when T given by itself one week after C

  Diarrhea

3

2 when T combined with D

0

 

1 when T combined with C

  1. T = taurolidine, D = doxorubicin, C = carboplatin.