Expression of Notch-1 and its clinical significance in different histological subtypes of human lung adenocarcinoma

Table 2 Results of univariate and multivariate Cox regression analysis of prognostic factors in LAD patients

Variables	Univariate analysis	Multivariate analysis
	P value	RR	95% CI	P value
Age (≥60/<60)	0.149	1.009	0.98-1.04	0.579
Gender (Male/Female)	0.627	2.011	0.86-4.71	0.108
Clinical stage (I/II + III + IV)	0.214	0.467	0.11-2.14	0.328
Tumor localization (Left/Right)	0.268	1.083	0.57-2.07	0.809
Tumor histology (APA/PPA/SPA/Others)	0.002*	1.248	0.91-1.72	0.177
Tumor differentiation (Poor/Moderate/Well)	0.016*	0.498	0.31-0.81	0.005*
Lymph node metastasis (Present/Absent)	0.021*	2.363	0.90-6.20	0.081
Recurrence (Present/Absent)	0.383	0.731	0.36-1.47	0.381
Smoking history (Present/Absent)	0.053	1.167	0.62-2.21	0.635
Notch-1 expression (Positive/Negative)	0.033	0.540	0.29-1.02	0.057

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