Multiple functions of hypoxia-regulated miR-210 in cancer

Table 1 Targets of miR-210 functioning as oncogene

Symbol	Description	Related function	Involved cell type
MNT [22]	MAX network transcriptional repressor	Regulate cell proliferation	HCT116
			HeLa
			HFF-pBABE
			ME-180
			786-O-pBABE
Casp8ap2 [31]	Caspase 8 associated protein 2	Regulate apoptosis	MSC
PTBP3/ROD1 [61]	Polypyrimidine tract binding protein 3/Regulator of differentiation 1	Regulate apoptosis	HEK-293
PTBP3/ROD1 [61]		Regulate apoptosis	HUVEC
E2F3 [32]	E2F transcription factor 3	Regulate apoptosis and cell proliferation	HPASMC
BNIP3 [36]	BCL2/adenovirus E1B 19 kDa interacting protein 3	Induce apoptosis	NPC
BNIP3 [36]	BCL2/adenovirus E1B 19 kDa interacting protein 3	Induce apoptosis	PC12
AIFM3 [27]	Apoptosis inducing factor, mitochondrion associated, 3	Induce apoptosis	SMMC-7721
			HepG2
			HuH7
EFNA3 [41, 64]	Ephrin-A3	Regulate angiogenesis	HUVEC
VMP1 [42]	Vacuole membrane protein 1	Regulate migration and invasion	SMMC-7721
VMP1 [42]	Vacuole membrane protein 1	Regulate migration and invasion	HuH-7
RAD52 [66]	RAD52 homolog (S. cerevisiae)	Involve in DNA repair	HeLa
RAD52 [66]	RAD52 homolog (S. cerevisiae)	Involve in DNA repair	MCF-7
PTPN1 [68]	protein tyrosine phosphatase, non-receptor type 1	Regulate immune response	IGR-Heu
PTPN1 [68]	protein tyrosine phosphatase, non-receptor type 1	Regulate immune response	NA-8
HOXA1 [68]	Homeobox A1	Regulate immune response	IGR-Heu
HOXA1 [68]	Homeobox A1	Regulate immune response	NA-8
TP53I11 [68]	tumor protein p53 inducible protein 11	Regulate immune response	IGR-Heu
TP53I11 [68]	tumor protein p53 inducible protein 11	Regulate immune response	NA-8

Abbreviations: MSC mesenchymal stem cell, HPASMC human pulmonary artery smooth muscle cell, NPCs neural progenitor cell, HUVEC human umbilical vein endothelial cell.

ISSN: 1756-9966