From: Characterization of the biological activity of a potent small molecule Hec1 inhibitor TAI-1
 | Cell lines | Cell type | RB | P53 | GI50(nM) |
---|---|---|---|---|---|
Strong sensitivity (GI50 < 50 nM) | K562 | Chronic myeloid leukemia | WT | Mut | 13 |
HeLa | Cervical cancer | Mut | Inactivated | 16 | |
T47D | Breast, metastatic-pleural, invasive ductal carcinoma | WT | Mut | 17 | |
U-937 | Acute myeloid leukemia | WT | Null | 22 | |
MDA-MB-453 | Breast, metastatic-effusion, adenocarcinoma | WT | Deletion | 24 | |
RPMI8226 | Acute myeloid leukemia | Mut | Mut | 27 | |
KG-1 | Myelogenous leukemia | Rearranged | Reduced/no | 29 | |
MDA-MB-468 | Breast, metastatic-pleural, invasive ductal carcinoma | Mut/no | Mut | 34 | |
HCT116 | Colorectal carcinoma | Low | WT | 39 | |
COLO205 | Colorectal carcinoma | WT | No | 40 | |
MDA-MB-231  | Breast, metastatic-pleural, invasive ductal carcinoma | WT | Mut | 43 | |
Moderate sensitivity (50 nM < GI50 < 100 nM) | PC3 | Prostate cancer | WT | Null | 60 |
MCF7 | Breast, metastatic-pleural, invasive ductal carcinoma | WT | Heterogenous. WT | 64 | |
NCI-H520 | Non-small cell lung cancer | WT | Reduced mRNA | 68 | |
ZR-75-30 | Breast, metastatic-ascites, invasive ductal carcinoma | WT | WT | 77 | |
ZR-75-1 | Breast, metastatic-ascites, invasive ductal carcinoma | WT | WT | 80 | |
Huh7 | Hepatocellular carcinoma | WT | Mut | 84 | |
BT474 | Breast, primary, invasive ductal carcinoma | WT | Mut | 86 | |
PLC/PRF/5 | Hepatocellular carcinoma | WT | Inactivated | 92 | |
Hep3B | Hepatocellular carcinoma | No | Deletion | 96 | |
Low sensitivity (100 nM < GI50 < 1 μM) | U2OS | Osteosarcoma | Less active | WT | 139 |
Hs578T | Breast, metastatic, invasive ductal carcinoma | WT | Mut | 143 | |
MV4-11 | Acute myeloid leukemia | WT | Mut | 231 | |
RS4;11 | Acute myeloid leukemia | WT | Mut | 254 | |
HepG2 | Hepatocellular carcinoma | WT | WT | 273 | |
MOLM-13 | Acute myeloid leukemia | WT | Mut | 315 | |
Resistant (GI50 > 1 μM) | A549 | Non-small cell lung cancer | WT | WT | >10 μM |
HCC1954 | Breast, invasive ductal carcinoma | Mut | WT | >10 μM | |
MDA-MB-361 | Breast, metastatic-brain, adenocarcinoma | WT | No | >10 μM | |
MOLT-4 | Acute lymphoblastic leukemia | WT | WT | >30 μM | |
N87 | Gastric cancer | WT | WT | >30 μM |