Journal of Experimental & Clinical Cancer Research

Table 4 Predictive values of biomarkers for Hec1 therapy

From: Characterization of the biological activity of a potent small molecule Hec1 inhibitor TAI-1

Hec1 expression				Hec1 +/- P53 expression
	Total	Mut	WT		Total	Mut	WT
Sensitive	17	16	1	Sensitive	25	25	0
Resistant	2	0	2	Resistant	5	1	4
	P value < 0.01				P value < 0.0001
P53 expression				Hec1 +/- RB expression
	Total	Mut	WT		Total	Mut	WT
Sensitive	25	22	3	Sensitive	25	18	7
Resistant	5	1	4	Resistant	5	0	5
	P value < 0.005				P value < 0.005
RB expression				Hec1 +/- RB +/- P53 expression
	Total	Mut	WT		Total	Mut	WT
Sensitive	25	7	18	Sensitive	25	25	0
Resistant	5	0	5	Resistant	5	1	4
	P value = 0.3				P value < 0.0001
RB +/- P53 expression
	Total	Mut	WT
Sensitive	25	23	2
Resistant	5	1	4
	P value < 0.005

NOTE: Drug-sensitive (TAI-1 GI₅₀ < 300 nM); Drug-resistant (TAI-1 GI₅₀ > 300 nM); Mut (high Hec1 protein expression level (> 50% HeLa expression), mutated/aberrant RB, or mutated/aberrant P53); WT (low Hec1 protein expression level (< 50% HeLa expression), wild type RB, or wild type P53). 2-tailed t test is utilized to determine significance in P values.

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ISSN: 1756-9966

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