Table 1 Genes with potentially broad impact on the confrontation and the inhibitory capacity

NFKBIA

Confrontation DEG

Co-regulated by RELA

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [Source: HGNC Symbol; Acc:7797]

IL1B

Confrontation DEG

Co-regulated by RELA

interleukin 1, beta [Source: HGNC Symbol; Acc:5992]

RELT

Confrontation DEG

Co-regulated by RELA

RELT tumor necrosis factor receptor [Source: HGNC Symbol; Acc:13764]

BHLHE40

Confrontation DEG

Co-regulated by RELA

basic helix-loop-helix family, member e40 [Source: HGNC Symbol; Acc:1046]

FOS

Connected to confrontation DEGs

Transcription factor

FBJ murine osteosarcoma viral oncogene homolog [Source: HGNC Symbol; Acc:3796]

SRF

Connected to confrontation DEGs

Transcription factor

serum response factor (c-fos serum response element-binding transcription factor) [Source: HGNC Symbol; Acc:11291]

FOSB

Confrontation DEG

Co-regulated by RELA

FBJ murine osteosarcoma viral oncogene homolog B [Source: HGNC Symbol; Acc:3797]

CYR61

Connected to confrontation DEGs

Pro-inflammatory signature (Erez et al., 2012)

cysteine-rich, angiogenic inducer, 61 [Source: HGNC Symbol; Acc:2654]

IKBKB

Connected to confrontation DEGs

Pro-inflammatory signature (Erez et al., 2012)

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [Source: HGNC Symbol; Acc:5960]

IKBKE

Connected to confrontation DEGs

Pro-inflammatory signature (Erez et al., 2012)

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon [Source: HGNC Symbol; Acc:14552]

IKBKG

Connected to confrontation DEGs

Pro-inflammatory signature (Erez et al., 2012)

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [Source: HGNC Symbol; Acc:5961]

IKBKG

Connected to confrontation DEGs

Pro-inflammatory signature (Erez et al., 2012)

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_b [Source: UniProtKB/TrEMBL; Acc:D3DWY0]

NR4A2

Connected to confrontation DEGs

Pro-inflammatory signature (Erez et al., 2012)

nuclear receptor subfamily 4, group A, member 2 [Source: HGNC Symbol; Acc:7981]

PDGFRA

Connected to confrontation DEGs

Pro-inflammatory signature (Erez et al., 2012)

platelet-derived growth factor receptor, alpha polypeptide [Source: HGNC Symbol; Acc:8803]

ANXA4

inhibition DEG

Co-regulated by FOXA1

annexin A4 [Source: HGNC Symbol; Acc:542]

CDK6

inhibition DEG

Co-regulated by FOXA1

cyclin-dependent kinase 6 [Source: HGNC Symbol; Acc:1777]

KAZN

inhibition DEG

Co-regulated by FOXA1

kazrin, periplakin interacting protein [Source: HGNC Symbol; Acc:29173]

RMND5A

inhibition DEG

Co-regulated by FOXA1

required for meiotic nuclear division 5 homolog A (S. cerevisiae) [Source: HGNC Symbol; Acc:25850]

TNS3

inhibition DEG

Co-regulated by FOXA1

tensin 3 [Source: HGNC Symbol; Acc:21616]

IL6

Connected to inhibition DEGs

Potential regulator

interleukin 6 (interferon, beta 2) [Source: HGNC Symbol; Acc:6018]

MAPK8

Connected to inhibition DEGs

Potential regulator

mitogen-activated protein kinase 8 [Source: HGNC Symbol; Acc:6881]

MAP2K4

Connected to inhibition DEGs

Potential regulator

mitogen-activated protein kinase kinase 4 [Source: HGNC Symbol; Acc:6844]

PRKCA

Connected to inhibition DEGs

Potential regulator

protein kinase C, alpha [Source: HGNC Symbol; Acc:9393]

YBX1

Connected to inhibition DEGs

Transcription factor

Y box binding protein 1 [Source: HGNC Symbol; Acc:8014]

GFI1

Connected to inhibition DEGs

Transcription factor

growth factor independent 1 transcription repressor [Source: HGNC Symbol; Acc:4237]

ESR1

Connected to inhibition DEGs

Transcription factor

estrogen receptor 1 [Source: HGNC Symbol; Acc:3467]

ETS1

Connected to inhibition DEGs

Transcription factor

v-ets avian erythroblastosis virus E26 oncogene homolog 1 [Source: HGNC Symbol; Acc:3488]

ETS2

Connected to inhibition DEGs

Transcription factor

v-ets avian erythroblastosis virus E26 oncogene homolog 2 [Source: HGNC Symbol; Acc:3489]

AR

Connected to inhibition DEGs

Transcription factor

androgen receptor [Source: HGNC Symbol; Acc:644]

GATA1

Connected to inhibition DEGs

Transcription fact or

GATA binding protein 1 (globin transcription factor 1) [Source: HGNC Symbol; Acc:4170]

GATA2

Connected to inhibition DEGs

Transcription factor

GATA binding protein 2 [Source: HGNC Symbol; Acc:4171]

GATA3

Connected to inhibition DEGs

Transcription factor

GATA binding protein 3 [Source: HGNC Symbol; Acc:4172]

PAX2

Connected to inhibition DEGs

Transcription factor

paired box 2 [Source: HGNC Symbol; Acc:8616]

JUN

Connected to inhibition DEGs

Transcription factor

jun proto-oncogene [Source: HGNC Symbol; Acc:6204]

STAT3

Connected to inhibition DEGs

Transcription factor

signal transducer and activator of transcription 3 (acute-phase response factor) [Source: HGNC Symbol; Acc:11364]

STAT5A

Connected to inhibition DEGs

Transcription factor

signal transducer and activator of transcription 5A [Source: HGNC Symbol; Acc:11366]

CAMK2A

Confrontation DEG

Involved in TGFbeta signaling, associated with survival

calcium/calmodulin-dependent protein kinase II alpha [Source: HGNC Symbol; Acc:1460]

CDK6

Confrontation DEG

Involved in TGFbeta signaling, associated with survival

cyclin-dependent kinase 6 [Source: HGNC Symbol; Acc:1777]

CDKN2B

Confrontation DEG

Involved in TGFbeta signaling, associated with survival

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) [Source: HGNC Symbol; Acc:1788]

NR4A1

Confrontation DEG

Involved in TGFbeta signiling, associated with survival

nuclear receptor subfamily 4, group A, member 1 [Source: HGNC Symbol; Acc:7980]

SMAD3

Confrontation DEG

Involved in TGFbeta signiling, associated with survival

SMAD family member 3 [Source: HGNC Symbol; Acc:6769]

TGFB1

Confrontation DEG

Involved in TGFbeta signiling, associated with survival

transforming growth factor, beta 1 [Source: HGNC Symbol; Acc:11766]

TGFB3

Confrontation DEG

Involved in TGFbeta signiling, associated with survival

transforming growth factor, beta 3 [Source: HGNC Symbol; Acc:11769]

EFNB2

inhibition DEG

Associated with survival

ephrin-B2 [Source: HGNC Symbol; Acc:3227]

TMEM220

inhibition DEG

Associated with survival

transmembrane protein 220 [Source: HGNC Symbol; Acc:33757]

TFAP2C

inhibition DEG

Associated with survival

transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) [Source: HGNC Symbol; Acc:11744]

RPSAP52

inhibition DEG

Associated with survival

ribosomal protein SA pseudogene 52 [Source: HGNC Symbol; Acc:35752]

SLC40A1

inhibition DEG

Associated with survival

solute carrier family 40 (iron-regulated transporter), member 1 [Source: HGNC Symbol; Acc:10909]

CYP1B1

inhibition DEG

Associated with survival

cytochrome P450, family 1, subfamily B, polypeptide 1 [Source: HGNC Symbol; Acc:2597]

CHAC1

inhibition DEG

Associated with survival

ChaC, cation transport regulator homolog 1 (E. coli) [Source: HGNC Symbol; Acc:28680]

CCL2

inhibition DEG

Associated with survival

chemokine (C-C motif) ligand 2 [Source: HGNC Symbol; Acc:10618]

PSAT1

inhibition DEG

Associated with survival

phosphoserine aminotransferase 1 [Source: HGNC Symbol; Acc:19129]

RCAN2

inhibition DEG

Associated with survival

regulator of calcineurin 2 [Source: HGNC Symbol; Acc:3041]

SCG2

inhibition DEG

Associated with survival

secretogranin II [Source: HGNC Symbol; Acc:10575]

AEBP1

inhibition DEG

Associated with survival

AE binding protein 1 [Source: HGNC Symbol; Acc:303]

MXRA8

inhibition DEG

Associated with survival

matrix-remodelling associated 8 [Source: HGNC Symbol; Acc:7542]

TBC1D1

inhibition DEG

Associated with survival

TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 [Source: HGNC Symbol; Acc:11578]

ITGA6

inhibition DEG

Associated with survival

integrin, alpha 6 [Source: HGNC Symbol; Acc:6142]

PLAUR

inhibition DEG

Associated with survival

plasminogen activator, urokinase receptor [Source: HGNC Symbol; Acc:9053]