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Table 2 Mean ± SD of body weight, colon surface area (length × width in cm), count of colonic tumours by gross and dissecting microscope, large ACF, number of tumour/colon surface area ratio (NT/CS), serum 25-OH vitamin D concentrations, liver enzymes and renal function parameters and in the different study groups

From: Vitamin D3 enhances the tumouricidal effects of 5-Fluorouracil through multipathway mechanisms in azoxymethane rat model of colon cancer

 

Normal group

AOM group

5-FU group

VitD group

5-FU/D group

Body weight (g)

231.57 ± 20.01

221.97 ± 23.01

238.42 ± 13.64

230.1 ± 22.2

229.5 ± 18.7

Colon surface area (cm2)

19.1 ± 2.2

18.89 ± 3.43

19.81 ± 1.84

21.5 ± 2.29

20.4 ± 4.1

Tumour count

Gross

N/A

12.5 ± 3.21

8.7 ± 2.9**

8.1 ± 2.5**

6.2 ± 1.6**,***

Dissecting Microscope

N/A

17.36 ± 4.6

8.8 ± 1.75**

10.04 ± 3.6**

5.78 ± 1.1**,***,****

Total

N/A

29.16 ± 2.92

16.66 ± 4.41**

19.33 ± 1.8**

11.5 ± 1.65**,***,****

large ACF (with ≥ 4 crypts/focus)

0

41.3 ± 8.0

21.3 ± 5.3**

19.7 ± 7.6**

11.2 ± 4.2**,***,****

NT/CS Ratio

N/A

1.5 ± 0.14

0.83 ± 0.14**

0.86 ± 0.06**

0.6 ± 0.18**,***,****

25-OH Vitamin D (ng/mL)

46.19 ± 8.1

36.6 ± 6.7*

35.7 ± 9.5*

68.5 ± 9.1*,**,***

65.8 ± 9.1*,**,***

ALP (IU/L)

122.6 ± 11.2

125.7 ± 9.7

120.8 ± 12.4

127.3 ± 11.9

121.6 ± 11.1

ALT (U/L)

67 ± 2.4

71.2 ± 6.7

68.7 ± 4.1

66.4 ± 5.3

67.3 ± 3.7

AST (U/L)

92.4 ± 24.2

105.8 ± 26.7

109 ± 21.6

103 ± 19.8

99 ± 11.9

Creatinine (mg/dL)

0.22 ± 0.03

0.2 ± 0.06

0.2 ± 0.03

0.19 ± 0.03

0.21 ± 0.05

Urea (mg/dL)

47.6 ± 5.1

52.3 ± 4

51.6 ± 9.5

47.3 ± 5.8

49.1 ± 3.7

BUN (mg/dL)

22.2 ± 2.4

24.4 ± 1.9

26.3 ± 4.4

22 ± 2.7

21.4 ± 2.1

  1. *P < 0.05 compared with normal; **P < 0.05 compared with AOM group, ***P < 0.05 compared with 5-FU group and ****P < 0.05 compared with VitD group