Fig. 5

Gab2 expression regulates ERK signaling and increases MMP7 and MMP9 expression in CRC cells. a Gab2 overexpression enhances MMP7 and MMP9 expression and activates ERK1/2, whereas knockdown of Gab2 inhibits MMP7 and MMP9 expression and reduces ERK1/2 activation. b and c The levels of phosphor‑AKT, phosphor‑ERK1/2, MMP7 and MMP9 were calculated. The data are representative of at least three different experiments ± SEM. *P < 0.05