Cell line | SN-38 | NSC 725776/LMP776 | NSC 743400/LMP400 | Epirubicin | Etoposide | |||||
---|---|---|---|---|---|---|---|---|---|---|
 | IC50 | RR | IC50 | RR | IC50 | RR | IC50 | RR | IC50 | RR |
HCT116-Wt | 0.05 ± 0.01 | 1 | 0.06 ± 0.03 | 1 | 0.17 ± 0.1 | 1 | 0.09 ± 0.01 | 1 | 6.3 ± 2.8 | 1 |
HCT116-SN38 | 3.4 ± 0.6 | 67 | 47 ± 46 a | 782 | 47 ± 46 | 280 | 0.2 ± 0.03 | 2.1 | 4.4 ± 3.5 | 0.7 |
HT29-Wt | 0.13 ± 0.06 | 1 | 0.03 ± 0.01 | 1 | 0.07 ± 0.04 | 1 | 0.18 ± 0.02 | 1 | 9.9 ± 3.7 | 1 |
HT29-SN38 | 7.3 ± 1.7 | 55 | 1.2 ± 0.7 | 36 | 0.14 ± 0.04 | 2 | 2.0 ± 0.9 | 11 | 38 ± 17 | 4 |
LoVo-Wt | 0.02 ± 0.004 | 1 | 0.02 ± 0.01 | 1 | 0.06 ± 0.02 | 1 | 0.11 ± 0.03 | 1 | 1.8 ± 1.9 | 1 |
LoVo-SN38 | 0.44 ± 0.2 | 20 | 0.09 ± 0.03 | 4.1 | 0.05 ± 0.03 | 0.8 | 0.95 ± 0.4 | 9 | 2.7 ± 1.6 | 1.5 |