Fig. 4

SiRNA targeting MTSS1 attenuates pulmonary metastasis following palliative resection in nude mice bearing human HCC xenograft. a, two pulmonary metastatic nodules (arrows, original magnification, × 200), bar, 50 μm. b, MMP2 activity was inhibited by siRNA targeting MTSS1 in vivo, †P = 0.003 compared with controls. c, qRT-PCR analysis demonstrated that MTSS1 expression was inhibited by siRNA in vivo, *P = 0.039 compared with controls. The bars indicate the means ± s.d