Cell cycle checkpoint in cancer: a therapeutically targetable double-edged sword

Table 1 Cell cycle checkpoint targeting drugs

	Target	Drug	References
S and G2/M checkpoint targeting drugs
	Chk1/2	UCN-01	[35, 37–40]
		ICP-1	[36]
		PF00477736	[41, 42]
		XL9844	[43]
		PD321852	[44]
		CEP3891	[45]
		AZD7762	[46]
		LY2603618	[47]
		Gö6976	[48]
		SCH900776 (MK-8776)	[49, 50, 53]
		CCT244747	[51]
	ATR	NU6027	[54]
	Wee1	MK-1775	[55–65]
Spindle assembly checkpoint targeting drugs
	Microtubular β-tubulin	Taxanes, Vinca alkaloids	[68, 77]
	Wee1	MK-1775	[92]

ISSN: 1756-9966