Fig. 5From: Che-1 sustains hypoxic response of colorectal cancer cells by affecting Hif-1α stabilizationModel to explain Che-1 involvement in HIF-1α stabilization. Under hypoxic conditions the depletion of Che-1 leads to a decrease of the ubiquitin E3 ligase SIAH2, allowing an increase of the prolyl isomerase PHD3. This results in a decrease of HIF-1α stabilization (bottom)Back to article page