Fig. 7

Schematic model of NKILA functions during the invasion-metastasis cascade in NSCLC. NKILA, which could be directly activated by TGF-β, inhibits NSCLC cell migration and invasion by binding the NF-κB: IκB complex and masking the phosphorylation sites of IκB from IKK to inhibit the IKK-induced IκB phosphorylation and NF-κB activation. Subdued NF-κB signal pathway activation lead to lower snail expression and then suppress NSCLC cell EMT