| No MMR N (%) | MMR N (%) | OR | 95% CI OR | P value | Number | Events N | HR | CI (95% HR) | P value |
---|---|---|---|---|---|---|---|---|---|---|
Univariate | ||||||||||
 Imatinib dose | ||||||||||
  Imatinib 400/day | 33 (73) | 75 (89) | 0 | 0 | 0 | 108 | 37 | 0 | 0 | 0 |
  Imatinib 200–300 mg/day | 12 (27) | 9 (11) | 2.86 | (1.16–7.89) | 0.0251 | 21 | 11 | 1.64 | (0.84–3.23) | 0.1482 |
 Risk score | ||||||||||
  Eutos Low | 31 (72) | 74 (88) | 0 | 0 | 0 | 105 | 34 | 0 | 0 | 0 |
  Eutos High | 12 (27) | 10 (12) | 2.86 | (1.12–7.32) | 0.0452 | 22 | 12 | 1.53 | (1.10–2.13) | 0.0121 |
  Sokal Low | 13 (31) | 42 (50) | 0 | 0 | 0 | 55 | 17 | 0 | 0 | 0 |
  Sokal Intermediate | 11 (26) | 30 (36) | 1.18 | (0.47–3.00) | 0.8130 | 41 | 9 | 0.79 | (0.46–2.13) | 0.5772 |
  Sokal High | 18 (43) | 12 (14) | 4.85 | (1.86–12.65) | 0.0019 | 30 | 19 | 1.69 | (1.22–2.36) | 0.0016 |
  Hasford Low | 11 (26) | 30 (36) | 0 | 0 | 0 | 41 | 11 | 0 | 0 | 0 |
  Hasford Intermediate | 18 (43) | 47 (56) | 1.04 | (0.43–2.52) | 1.0000 | 65 | 21 | 1.13 | (0.55–2.35) | 0.7344 |
  Hasford High | 13 (31) | 7 (8) | 5.06 | (1.60–15.99) | 0.0058 | 20 | 13 | 1.71 | (1.14–2.55) | 0.0095 |
 SNPs | ||||||||||
  rs460089 | ||||||||||
   GG | 35 (78) | 35 (42) | 0 | 0 | 0 | 70 | 37 | 0 | 0 | 0 |
   CC | 4 (9) | 11 (13) | 0.36 | (0.10–1.25) | 0.1530 | 15 | 2 | 0.43 | (0.21–0.87) | 0.0197 |
   GC | 6 (13) | 38 (45) | 0.15 | (0.06–0.43) | <0.0001 | 44 | 9 | 0.28 | (0.13–0.58) | 0.0006 |
  rs13180043 | ||||||||||
   CC | 35 (78) | 77 (92) | 0 | 0 | 0 | 112 | 41 | 0 | 0 | 0 |
   CT | 10 (2) | 7 (8) | 3.14 | (1.11–8.94) | 0.0321 | 17 | 10 | 1.91 | (0.95–3.81) | 0.0677 |
  rs2631365 | ||||||||||
   TT | 19 (42) | 31 (37) | 0 | 0 | 0 | 50 | 20 | 0 | 0 | 0 |
   CC | 6 (14) | 13 (15) | 0.75 | 0.24–2.32 | 0.7808 | 19 | 4 | 0.61 | (0.35–1.05) | 0.0767 |
   TC | 20 (44) | 40 (48) | 0.82 | 0.73–1.79 | 0.6903 | 60 | 24 | 1.00 | (0.55–1.82) | 0.9900 |
Multivariate | ||||||||||
 Imatinib dose | ||||||||||
  Imatinib 400/day | 33 (73) | 75 (89) | 0 | 0 | 0 | 108 | 37 | 0 | 0 | 0 |
  Imatinib 200–300 mg/day | 12 (27) | 9 (11) | 4.17 | (1.42–12.18) | 0.0191 | 21 | 11 | 1.98 | (1.01–3.90) | 0.0481 |
 SNP | ||||||||||
  rs460089 | ||||||||||
   GG | 35 (78) | 35 (42) | 0 | 0 | 0 | 70 | 37 | 0 | 0 | 0 |
   CC | 4 (9) | 11 (13) | 0.53 | (0.27–1.02) | 0.0740 | 15 | 2 | 0.40 | (0.20–0.83) | 0.0141 |
   GC | 6 (13) | 38 (45) | 0.28 | (0.06–0.42) | 0.0003 | 44 | 9 | 0.28 | (0.14–0.59) | 0.0008 |