Fig. 4
The anti-apoptotic bcl-2 family and autophagy inhibitor obatoclax enhances the activity of KP46 in the majority of the tested OS cell models. The two compounds were either applied alone or in combination at the indicated concentrations for 72 h continuous drug exposure. Cell viability was determined by an MTT-based survival assay. Dose-response curves at the left are compared to the respective combination indices (CI) calculated by CalcuSyn Software at the right panels