Fig. 7

NLRP3 inflammasome promotes OSCC growth and restrains the antitumor effect of 5-FU in vivo. a Schematic representation for the establishment of 4-NQO-induced oral cancer mouse model and 5-FU treatment regimens. b Tumor incidence in wild-type, Nlrp3 ^−/− and Caspase1 ^−/− mice. c Representative photographed pictures of tongues with tumors from mice treated with or without 5-FU. d Digital outline of each representative tongue from control and 5-FU treated mice as described in panel C. Red lining indicated tumor burden in the respective tongue. e Tumor areas as indicated in 7B were quantified by ImageJ software in arbitrary units. The inhibition rate of tumor area in wild type, Nlrp3 ^−/− and Caspase1 ^−/− mice after 4 weeks of 5-FU treatment. Five mice were included in each group, and results are representative of three experiments (*P < 0.05, **P < 0.01)