Fig. 1

CTHRC1 is commonly upregulated in ESCC tissues and overexpression of CTHRC1 predicts poor prognosis. a Small RNA interference (RNAi) screening targeting Collagen triple helix repeat containing-1 (CTHRC1), Neural EGFL like 2 (NELL2), DLG associated protein 5 (DLGAP5), DEP domain containing 1 (DEPDC1), Zic family member 2 (ZIC2) and Centrosomal protein 55 (CEP55) in KYSE70, KYSE510 and KYSE30 cells. b Representative immunohistochemical (IHC) images of CTHRC1 staining in ESCC tumour tissues and non-tumour tissues. c The number and percent of patients with higher, equal or lower CTHRC1 staining in ESCC tumour tissues compared with non-tumour tissues. T: tumour tissue; N: non-tumour tissue. d Overall survival analysis based on the expression level of CTHRC1 measured by IHC in 204 ESCC patients. Survival rates were determined by the Kaplan-Meier survival analysis. P = 0.020, log-rank test