Table 1 Major microbial differences between cancer tissues and non-cancer tissues
Tumor types | Sample | Major microbial differences between tumors and adjacent non-cancer tissues | Major microbial differences between tumors and tissues from healthy people | Reference |
|---|---|---|---|---|
Breast cancer | 20 tumor tissues and adjacent 20 non-tumor tissues from patients with breast cancer | Increased: Methylobacterium radiotolerans Decreased: Sphingomonas yanoikuyae | Â | [37] |
Breast cancer | Data of 668 breast tumor tissues and 72 adjacent non-tumor tissues from TCGA | Increased: Phylum Proteobacteria Decreased: Phylum Actinomycetes | Â | [38] |
Colorectal cancer | 31 tumor mucosal samples and 20 adjacent non-tumor mucosal samples from patients with colorectal cancer, and 30 mucosal samples from healthy controls | Increased: Genera Lactococcus and Genera Fusobacterium Decreased: Genera Pseudomonas and Genera Escherichia-Shigella | Increased: Phylum Firmicutes and Phylum Fusobacteria Decreased: Phylum Proteobacteria | [39] |
Colon cancer | Tumor mucosal samples and adjacent non-tumor mucosal samples from 7 patients with colitis-associated colon cancer (CAC) or 10 patients with sporadic colon cancer (SC), and colon mucosal samples from 10 healthy controls | No significant difference | CAC: Increased: Phylum Proteobacteria CAC: Decreased: Phylum Firmicutes and Phylum Bacteroidetes SC: Increased: Phylum Fusobacteria Decreased: Phylum Bacteroidetes | [40] |
Cervical cancer or intraepithelial neoplasia | 30 cervicovaginal swab specimens from patients with invasive squamous cell carcinoma or cervical intraepithelial neoplasia, and 20 normal cervical tissues from healthy controls | Â | Increased: Gardnerella vaginalis, Peptostreptococcus anaerobius, and Porphyromonas uenonis Decreased: Lactobacillus crispatus | [41] |
Lung cancer | Bronchoalveolar fluid from 20 patients with lung cancer and 8 patients with benign lung mass | Â | Compared with benign lung masses: Increased:Phylum Firmicutes, Phylum TM7, Genera Veillonella and Genera Megasphaera | [42] |
Lung cancer | 143 tumor tissues from patients with lung cancer, 143 adjacent non-tumor tissues from patients with lung cancer, and 33 lung tissues from healthy controls | No significant difference | Increased:Phylum Proteobacteria Decreased:Phylum Firmicutes | [43] |
Thyroid carcinoma | Data of thyroid tumor tissues and adjacent normal tissues from GDC | Decreased: Micrococcus luteus, Frankia sp., Anabaena sp. K119, and uncultured Gammaproteobacteria bacterium | Â | [44] |