Fig. 1
From: The path to the clinic: a comprehensive review on direct KRASG12C inhibitors
The G domain corresponds to the initial 166–168 residues. Bordering the nucleotide-binding pocket are four main regions: the phosphate-binding loop (P-loop, residues 10–17), switch I (residues 30–38), switch II (residues 60–76) and the base-binding loops (residues 116–120 and 145–147). The two switch regions regulate all known nucleotide-dependent interactions between RAS and its binding partners. The remaining residues in the carboxy-terminal constitutes the HVR, including the CAAX motif, a membrane anchor sequence. Abbreviations: HVR, hypervariable region; CAAX, C: cysteine amino acid, A: aliphatic amino acid, X: amino acid dictating whether farnesylated or geranylated