Fig. 3

A Schematic diagram of the synthesis of Cu@CuOx-ECL1i, Cu@CuOx-ECL1i-Gem, and 64Cu-radiolabeled nanoparticles. B STEM of Cu@CuOx-ECL1i. C Number-average hydrodynamic diameter of Cu@CuOx-ECL1i. D In vitro TA-PEG-Gem release profiles of Cu@CuOx-ECL1i-Gem under physiological and acidic conditions. E Tumor growth (F) and mouse survival, curves of KI-implanted mice after being treated with Cu@CuOx-ECL1i-Gem, Cu@CuOx-ECL1i, Cu@CuOx-Gem, gemcitabine (7 mg/kg body weight, IV), gemcitabine (100 mg/kg body weight, IP), and saline. First treatment with Cu@CuOx-ECL1i-Gem started at 10 days’ post-tumor implantation. The Cu@CuOx-Gem and second treatment began at 7 days’ post-tumor implantation. G H&E staining of the tumor slices from mice treated with Cu@CuOx-ECL1i-Gem, H gemcitabine (100 mg/kg body weight), and (I) saline [129]