Fig. 3

Cell fates and multistep differentiation processes in physiologic development of the sympatho-adrenal lineage in humans. Cell type populations involved in physiologic development of the sympatho-adrenal lineage, here illustrated, include: bipotent cell progenitors, sympatho-adrenal (SA) progenitors, and SNPCs, as emerged from lineage tracing in mouse embryos; SCPs, transient cells and cells at different developmental stages toward the final differentiated state, based on scRNA-seq studies with spatial transcriptomics conducted in human embryos. In the developing adrenal medulla (AM) there is a co-localization of SCP-derived components, sympathetic and chromaffin at different degrees of differentiation, which are outlined as solid painted circles. Developmental human timeline expressed as wpc: weeks post conception. Basic cell icons have been retrieved from https://app.biorender.com and next modified by Adobe Photoshop CC 2019