Table 2 Specifier markers characterizing human sympatho-adrenal cell types

SNPCs

RET PHOX2B ASCL1 HAND2 GATA3

SOX10- PLP1-

Sympathetic neuroblasts extra-adrenal

RET PHOX2B TH

SOX10- PLP1- SGC10-

Sympathetic neurons/ganglia/SRG

RET SCG10 ASCL1 PHOX2B TH DBH

SOX10- PLP1-

SCPs

SOX10 PLP1 ERBB3 FOXD3 ASCL1 PHOX2B

RET- ISL1- HAND2-

Cycling SCPs

SOX10 PLP1 ERBB3 ASCL1 MKI67 TOP2A

ISL1- HAND2-

Schwann cells

SOX10 PLP1 GFAP

PHOX2B-

Bridge cells

SOX10 PLP1 PHOX2B HAND2 ISL1 ASCL1 ERBB4 VGF MYCN ALK

RET- TH-

Early chromaffin cells

CHGA CHGB PENK TH DBH

SOX10- PLP1- RET-

Early Neuroblasts intra-adrenal

RET ASCL1 PHOX2B HAND2 GATA3 TH ISL1 ALK MEIS2 NPY PRPH NEFM STMN2 SYN3 CCND1

SOX10- PLP1-

Cycling chromaffin cells

CHGA CHGB PENK TOP2A

SOX10- PLP1- RET-

Cycling neuroblasts

PRPH ISL1 RET ASCL1 PHOX2B HAND2 GATA3 MKI67 TOP2A

SOX10- PLP1-

Late chromaffin cells

CARTPT INSM1 CHGA PNMT PENK ASCL1 PHOX2B TH DBH CDKN1C

SOX10- PLP1- RET-

Late Neuroblasts

SYN3 IL7 RET PHOX2B GATA3 PRPH STMN2 ISL1 TH NTRKI GAP43 SOX4 SOX11 TFAP2B

SOX10- PLP1- ALK-