Fig. 5
From: The role of TBK1 in cancer pathogenesis and anticancer immunity
The role of TBK1 in the pathogenesis of cancer. In cancer cells, TBK1 promotes tumor cell growth by: 1) stimulating proliferation and survival signaling; 2) inducing the production tumor-promoting cytokines; and 3) promoting the secretion of immunosuppressive inflammatory cytokines. In immune cells, 4) TBK1 regulates the production of immunoregulatory factors that either inhibit or promote the anticancer effects of CD8+ T cells. However, the role of TBK1 in the antitumor activity of CD8+ T cells has not been adequately studied