Table 4 Summary of the in vitro antineoplastic activities of TBK1 inhibitors

AMX

Inhibits growth of ALL cells (RS4;11 and SEM), displays synergism with TMZ in glioblastoma cells (U87MG) and patient samples, and attenuates the metastatic phenotype in prostate cancer cells (PC3 and DU145).

[247, 272, 273]

Compound II

Can induce apoptosis in lung cancer cells (HCC44, H1993, H2073, and H441), including H358 (K-RAS^G12C) and SK-LU-1 (K-RAS^G12D).

[229]

AZ909

Significantly attenuates the growth of N-RAS-activated melanoma cells (WM1366, SBcl2, and WM1346), displays synergism with MEK inhibitors.

[223]

MMB/CYT387/GS-0387

Decreases viability of AML cells (OCI-AML5, MOLM13, MOLM14, and KASUMI-1).

[15]

UNC6587 PROTAC

Selectively slows the growth of VHL^null ccRCC cells (UMRC6) while leaving VHL^+/+-restored UMRC6 cells unaffected.

[80]