Fig. 1

Landscape of gene modulation by epigenetic drugs in melanoma cell lines. Each pie chart shows the % of genes significantly modulated in each of 20 families or functional groups (red = upregulated genes, green = downregulated genes) by each drug in the two cell lines (VRG100 and CST30), on the basis of FC and p value. The 20 gene families are further classified into 7 groups identified on the right hand side of the Figure: 1, epigenetic regulation; 2, proliferation; 3, immune regulation; 4, enzymes; 5, structural components; 6, adhesion; 7, differentiation