Fig. 4

Comparison of URs activated or inhibited by guadecitabine vs JQ1 and by guadecitabine vs givinostat in melanoma cell line VRG100. A. Scatter plot of significantly modulated URs by Guadecitabine and JQ1. The grey square represents the area of no-significance, i.e. URs with Z < |2| and p value > 0.05. URs in the red square, representing factors showing activation by guadecitabine and inhibition by JQ1, are listed in the table on right of the scatter plot. B. Scatter plot of significantly modulated URs by guadecitabine and givinostat. URs in red square 1 represent factors showing activation by both guadecitabine and givinostat; URs in red square 2 represent factors activated only by guadecitabine and not by givinostat. URs in square 1 and 2 are listed in the tables on the right side of the scatter plot