Fig. 7

Activation of guadecitabine-specific UR signature molecules in on-treatment tumor biopsies from responding compared to non-responding patients in the NIBIT-M4 trial. A, B. Z score values of guadecitabine-activated URs as identified in Fig. 5A (A) or in Fig. 5B (B) based on differential gene expression analysis in tumor samples (obtained at w0, w4 and w12) from responding vs non-responding patients. Only significant URs (Z score > 2) are shown by the indicated color code. C. Scatter plot of Z score values of activated URs in responding vs non-responding patients at w4 vs. wk12