Table 1 Univariate and multivariate cox analysis of clinicopathological features for OS (TCGA cohort)

Gender

643

0.769

 Female

301

Reference

 Male

342

1.054 (0.744–1.491)

0.769

Age

643

< 0.001

 <= 65

276

Reference

Reference

 > 65

367

1.939 (1.320–2.849)

< 0.001

1.363 (0.456–4.069)

0.579

Anatomic neoplasm subdivision

420

0.101

 Ascending Colon&Descending Colon

108

Reference

 Rectum&Sigmoid Colon&Transverse Colon

312

0.666 (0.414–1.071)

0.093

Histological type

632

0.281

 Adenocarcinoma

549

Reference

 Mucinous adenocarcinoma

83

1.320 (0.810–2.151)

0.266

Pathologic T stage

640

0.001

 T1&T2

131

Reference

Reference

 T3&T4

509

2.468 (1.327–4.589)

0.004

0.271 (0.057–1.282)

0.1

Pathologic N stage

639

< 0.001

 N0

367

Reference

Reference

 N1&N2

272

2.627 (1.831–3.769)

< 0.001

4.370 (0.891–21.446)

0.069

Pathologic M stage

563

< 0.001

 M0

474

Reference

Reference

 M1

89

3.989 (2.684–5.929)

< 0.001

1.827 (0.410–8.148)

0.43

Lymphatic invasion

581

< 0.001

 No

349

Reference

Reference

 Yes

232

2.144 (1.476–3.114)

< 0.001

2.197 (0.704–6.859)

0.175

CEA level

414

< 0.001

 <= 5

260

Reference

Reference

 > 5

154

2.620 (1.611–4.261)

< 0.001

1.035 (0.283–3.783)

0.958

Primary therapy outcome

312

< 0.001

 PD&SD

38

Reference

Reference

 PR&CR

274

0.109 (0.058–0.202)

< 0.001

0.089 (0.027–0.291)

< 0.001

EFTUD2

643

0.427

 Low

321

Reference

Reference

 High

322

1.101 (0.779–1.556)

0.013

1.464 (1.024–2.095)

0.029