Fig. 1

Establishment of paclitaxel and gemcitabine resistant PDAC models. A Graphical representation of the methodology used for generation of PR and GR models. B Growth curves of PR (upper panel) and GR (lower panel) cells, together with the parental cells, exposed to increasing concentrations of gemcitabine or paclitaxel. C Sensitivity of PR cells to gemcitabine and GR cells to paclitaxel. B-C Mean and SD of triplicates are shown. IC₅₀ values were calculated as mean of 3 independent experiments, each performed in triplicate