Fig. 4

The identification of has-circ-0011536 in exosomes and VGF in DRGs. A The volcano plot and clustered heatmap compare the expression of circRNAs for lenti-Gli1 and EV-Gli1. KEGG analysis of DEGs. The circRNAs were classified according to the Pearson correlation. B, C qRT-PCR was used to assess relative expression levels of circRNAs in cells and exosomes. D Schematic illustration of circPRMT5 locus with specific primers. E Volcano plot compares the expression of mRNAs for lenti-Gli1 and EV-Gli1-induced DRG cells. KEGG analysis of DEGs. F qRT-PCR was used to assess relative expression levels of mRNAs in DRG cells. *P < 0.05 for lenti-Gli1 vs. EV-Gli1 (by Sangerbox [21])