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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Hedgehog-Gli1-derived exosomal circ-0011536 mediates peripheral neural remodeling in pancreatic cancer by modulating the miR-451a/VGF axis

Fig. 5

The screening and identification of miR-451a in DRG cells. A qRT-PCR was used to assess relative expression levels of has-circ-0011536 and VGF. *P < 0.05 for EV-Gli1 + OE-circ vs. EV-Gli1 + OE-NC; #P < 0.05 for lenti-Gli1 vs. EV-Gli1; ^P < 0.05 for lenti-Gli1 + si-NC vs. lenti-Gli1 + si-circ. B The axon length of DRG (200 ×). C qRT-PCR was used to assess relative expression levels of mmu-circ-0001261 and VGF. D, G Protein levels of VGF were measured by Western blotting. E qRT-PCR was used to assess relative expression levels of miRNAs and VGF. *P < 0.05 for OE-NC + lenti Gli1 exosomes vs. OE-NC; #P < 0.05 for OE-circ vs. OE-NC. F qRT-PCR was used to assess relative expression levels of mmu-miR-451a and VGF. *P < 0.05 for OE-NC + miR-451a mimics vs. OE-NC + miR-451a NC; #P < 0.05 for OE-circ + miR-451a mimics vs. OE-circ + miR-451a NC

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