Fig. 9

Evaluation of CODRP index-based drug sensitivity prediction platform by applying ALK-targeted drug-resistant patient sample. (A) Drug sensitivity test of three ALK-targeted drugs using LC_08PE organoid derived from patients with positive ALK. (B) The results of the drug sensitivity test based on the conventional AUC index predicted sensitive drug response to alectinib; in the proposed CODRP index-based drug sensitivity test, all three ALK-targeted drugs were predicted as a resistance group. (C) LC_08PE patient was prescribed alectinib after palliative surgery and showed resistance to alectinib; the drug sensitivity test using LC_08PE organoid derived from the MPE of LC_08PE patient showed resistance to alectinib