Fig. 7

Proposed mechanisms of RRM2 inhibition by COH29 in ATRT cells via DNA damage induction and apoptosis activation. A The correlation of mRNA gene expression between RRM2 and BRCA1 in eleven ATRT cell lines. Data were analyzed from the project Expression Public 23Q2 dataset (DepMap). B Pearson correlation test between the RNA expression level of BRCA1 and RRM2 in human TMU-Taipei VGH cohort (n = 28) and PedcBioPortal_PBTA_cohort (n = 67). RNA expression was normalized using logarithm base 2. C The correlation of BRCA1 mRNA level with patient’s overall survival (OS) in TMU-Taipei VGH cohort (n = 26), and PBTA cohort from PedcBioPortal (n = 48). D Proposed schematic of COH29 treatment induces DNA damage and activates apoptosis in ATRT