Fig. 6

The impact of loratadine on lung cancer survival outcomes and underlying mechanisms. The administration of loratadine demonstrates a positive correlation with enhanced survival rates in individuals diagnosed with lung cancer. Loratadine could potentially foster complex crosstalk between apoptosis and pyroptosis, with caspase-8 playing a key role. This is achieved through the regulation of PPARγ levels, promoting gsdmd transcription and caspase-8 activation