Fig. 7

PPP1CA is critical for circGPRC5A-mediated promotion of CRC. A–D CCK-8, colony formation, Transwell, and wound healing assays were conducted to investigate the effects of PPP1CA on circGPRC5A-mediated proliferation and migration of HT29 and HCT116 cells. E–J Experimental results of the effects of PPP1CA on circGPRC5A-mediated proliferation and migration of HT29 and HCT116 cells were quantified and presented using a bar chart. Values are shown as the mean ± SD based on three independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001