Fig. 1

NK cell gene signature correlates with worse prognosis in uveal melanoma A Forest plots for three NK cell gene signatures and their influence on overall survival in 33 different cancer types across TCGA-Pan cancer database. Heatmap shows respective p-values based on cox proportional hazards model. B Relative scores for the three different NK cell gene signatures comparing UM samples with or without the loss of chromosome 3. Mann–Whitney was used to test for significance (n = 80). Signature 1: Böttcher 2018, signature 2: Cursons 2019, and signature 3: Zheng 2019. C Volcano plot showing correlation and significance between NK cell gene signature (Böttcher 2018) with a TGFβ-EMT gene signature in the 33 different cancer types of TCGA-Pan cancer cohort. Spearman correlation was used for every cancer cohort of the TCGA dataset. Cancer types with significant spearman R value of > 0.4 or < -0.4 were highlighted