Fig. 1

Modulation of Kinase Signaling Pathways by HDAC Inhibitors. HDAC inhibitors exhibit synergistic interactions with EGFR and AXL inhibitors, enhancing their therapeutic potential [92]. Additionally, HDAC inhibitors downregulate EGFR expression and attenuate ERK signaling, potentially disrupting downstream cascades [87, 93, 95]. HDAC inhibitors also synergize with PI3K inhibitors, leading to a reduction in phospho-AKT signaling [83]. These observations highlight the intricate regulatory role of HDAC inhibitors in modulating diverse aspects of kinase signaling networks for potential therapeutic applications

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