Fig. 2

BET Protein Interactions with Key Signaling Pathways in High-Grade Gliomas. BET proteins influence transcriptional processes by recognizing acetylated lysine residues on histones and recruitment of transcriptional factors, including P-TEFb, to activate RNA polymerase [99, 100]. In models of medulloblastoma and HGG, the inhibition of BET proteins impacts the VEGFR/PI3K/AKT signaling pathway [107] and the transcription factor MYC [111]. Furthermore, synergistic effects are observed upon combining BET inhibitors with kinase inhibitors of MEK, AURKA and CDKs, suggesting potential therapeutic strategies [106, 108, 111]

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