Fig. 4

Multifaceted Role of EZH2 in Kinase-Mediated Regulation. As a methyltransferase, EZH2 facilitates the compaction of chromatin by adding methyl groups to histone protein, H3K27. This epigenetic modification condenses the chromatin structure, affecting gene expression patterns. In this manner, EZH2 can exert its influence on kinase signaling pathways. It downregulates PTEN expression, leading to activation of the PI3K/AKT pathway [129]. Beyond its chromatin-related functions, EZH2 acts as a methyltransferase for non-histone protein, STAT3, increasing its activity in gene regulation [134]. Moreover, the kinase MELK plays a crucial role, as it phosphorylates EZH2, enhancing its methyltransferase activity and amplifying its effect [131, 133]. TF – transcription factor

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